中国血液流变学杂志

目的　通过与奥美拉唑三联 7天疗法比较 ,观察雷贝拉唑四联 5天疗法根除幽门螺杆菌 (H .pylori)的疗效。方法　采用单中心、随机、平行对照研究法。 96例经快速尿素酶和病理学检查确定为H .pylori阳性患者分为两组 ;雷贝拉唑 (商品名 :波利特 )实验组 (RCTB组 ,50例 )和奥美拉唑 (商品名 :洛赛克 )对照组 (OCT组 ,46例 )。实验组 ;雷贝拉唑 10mg +替硝唑50 0mg +克拉霉素 2 50mg +枸橼酸铋钾 110mg ,每日两次 ,连续 5天 ,对照组 ;奥美拉唑 2 0mg +替硝唑 50 0mg +克拉霉素 2 50mg ,每日两次 ,连续 7天。并于用药后 1月行14C呼气实验检测感染是否治愈。结果　 92例完成全部治疗方案 ,4例失访。H .py lori根除率 :14C呼气实验检测结果示RCTB组 93 .7% ,OCT组 90 .9% ,两组间无显著性差异 (P >0 .0 5)。结论　两组治疗方案均能有效根除H .pylori。

Aims To compare two different regimens of rabeprazole -based quadruple 5-day therapy versus omeprazole-based triple 1-week therapy for the eradication of H.pylori infection. Methods Ninety six patients with H.pylori infection proven by both patho logy and rapid urease were assigned to receive one of the tow regimens: tinidazo le 500mg bid and clarithromycin 250mg bid and bismuth 110mg bid with rabeprazole (Pariert) 10mg bid (RCTB group) for 5 days or tinidazole 500mg bid and clarithr omycin 250mg bid with omeprazole (Losec) 20mg bid (OCT group) for one week. The eradication rates of H.pylori were evaluated by 14 C-UBT on the firs t month after completion of treatments.Results Ninety tow patie nts completed the trial .Four patients dropped out. The eradication rates of H .pylori in RCT B group and in OCT group were 93.7% and 90.9% respectively. There was no statist ically significant difference between the two groups (P>0.05).Concl usion Both tow regimens can eradicate H.pylori effectively.